Dr. Jonathan Caguiat

Dr. Jonathan Caguiat - profile photo

Dr. Jonathan Caguiat


Chemical & Biological Sciences

Ward Beecher Hall 3111

phone: (330) 941-2063



Dr. Jonathan Caguiat is a Professor in the Department of Biological Sciences at Youngstown State University (YSU). In 1987, He received his Bachelor’s degree in Molecular Biology from the University of Michigan and studied an ATPase enzyme found in spinach chloroplasts. In 1995, he earned his Ph.D. in Microbiology from Michigan State University where he studied selenite resistance in Enterobacter sp. YSU, a bacterial strain that was isolated from a heavy metal contaminated site in Oak Ridge, TN. As a postdoctoral fellow at the University of Georgia, he studied the protein, MerR, which regulates the expression of mercury resistance. In 2000, he worked for Pall Life Sciences in Ann Arbor, MI developing molecular biology applications for filtration products. Then, in 2001, he worked at New Target Technologies, a startup company that searched for drug targets to combat diabetes and obesity. He began teaching at YSU in 2004 and is using transposon mutagenesis to identify heavy metal resistance genes found in the multi-metal resistant bacterial strains, Stenotrophomonas maltophilia Oak Ridge strain 02 and Enterobacter sp. YSU.

  • Education
    • 1995

      Ph D, Microbiology

      Michigan State University

    • 1988

      BS, Biology

      University of Michigan

  • Professional Positions
    • 2022 -

      Youngstown State University


    • 2010 - 2022

      Youngstown State University

      Associate Professor

    • 2004 - 2010

      Youngstown State University

      Assistant Professor

    • 2004 - 2010

      Youngstown State University

      Assistant Professor

    • 2002 - 2003

      NT2 Incorporated

      Senior Scientist

    • 2000 - 2002

      Pall Life Sciences

      Staff Scientist

    • 1995 - 2000

      University of Georgia

      Postdoctoral Research Associate

    • 1989 - 1995

      Michigan State University

      Graduate Assistant

  • Intellectual Contributions
    • 2021

      "Potential Whole-Cell Biosensors for Detection of Metal Using MerR Family Proteins from Enterobacter sp. YSU and Stenotrophomonas maltophilia OR02."

      G. Baya, S. Muhindi, V. Ngendahimana, J. Caguiat

      Micromachines, volume 12, issue 2, p. 142

    • 2019

      "Microbiology for the Health Professions Laboratory Manual"

      D. Fagan, J. Caguiat

      Kendall Hunt Publishing Company, p. 73

    • 2016

      "Identification of peptide sequences that selectively bind topentaerythritol trinitrate hemisuccinate-a surrogate of PETN,via phage display technology"

      G. Kubas, W. Rees, J. Caguiat, D. Asch, D. Fagan, P. Cortes

      Peptide Science, volume 108, issue 2, p. e22997

    • 2014

      "Caguiat JJ. Generation of Enterobacter sp. YSU auxotrophs using transposon mutagenesis."

      J. Caguiat

      J Vis Exp, volume 92, p. e51934

    • 2009

      "Proteomic profiling of L-cysteine induced selenite resistance in Enterobacter sp. YSU"

      A. Jasenec, N. Barasa, S. Kulkarni, N. Shaik, S. Moparthi, V. Konda, J. Caguiat

      Proteome Science, volume 7, p. 30

    • 2009

      "Comparison of Two Multimetal Resistant Bacterial Strains: Enterobacter sp. YSU and Stenotrophomonas maltophilia ORO2"

      A. Holmes, A. Vinayak, C. Benton, A. Esbenshade, C. Heinselman, D. Frankland, S. Kulkarni, A. Kurtanich, J. Caguiat

      Curr Microbiol, volume 59, issue 5, p. 526-531

    • 2003

      "Engineered single chain, antiparallel, coiled coil mimics MerR metal binding site."

      L. Song, J. Caguiat, Z. Li, J. Shokes, R. Scott, L. Olliff, A. Summers

      Journal of Bacteriology, volume 186, issue 6, p. 1861-1868

    • 1999

      "Cd(II)-responsive and constitutive mutants implicate a novel domain in MerR."

      J. Caguiat, A. Watson, A. Summers

      Journal of Bacteriology, volume 181, issue 11, p. 3462–3471

    • 1989

      "ATP hydrolysis catalyzed by a beta subunit preparation purified from the chloroplast energy transducing complex CF1.CF0"

      W. Frasch, J. Green, J. Caguiat, A. Mejia

      The Journal of Biological Chemistry, volume 264, issue 9, p. 5064-506

  • Professional Service
    • 2022 - 2022


    • 2021 - 2021


    • 2020 - 2020


    • 2019 - 2019